{"id":2038,"date":"2024-01-15T11:06:24","date_gmt":"2024-01-15T11:06:24","guid":{"rendered":"https:\/\/www.biophysium.com\/?page_id=2038"},"modified":"2024-06-16T17:16:50","modified_gmt":"2024-06-16T17:16:50","slug":"mitochondrial-function","status":"publish","type":"page","link":"https:\/\/www.biophysium.com\/fr\/mitochondrial-function\/","title":{"rendered":"\u00c9valuation mitochondriale"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” admin_label=”intro” module_id=”nutrition” _builder_version=”4.10.5″ background_color=”#000000″ background_enable_image=”off” parallax=”on” custom_padding=”|||” global_colors_info=”{}”][et_pb_fullwidth_header title=”Biophysium” subhead=”Mitochondrial Evaluation” content_max_width=”900px” _builder_version=”4.10.5″ title_font=”Poppins||on|on|||||” title_text_color=”#FFFFFF” title_font_size=”24px” title_letter_spacing=”4px” title_line_height=”2em” content_font=”||||||||” content_text_color=”#85C07E” subhead_font=”Poppins|600||||on|||” subhead_text_color=”#FFFFFF” subhead_font_size=”59px” subhead_line_height=”1.6em” background_color=”rgba(126,190,197,0)” background_color_gradient_direction=”90deg” background_image=”https:\/\/www.biophysium.com\/wp-content\/uploads\/2024\/04\/Black-Minimal-Motivation-Quote-LinkedIn-Banner-1.jpg” background_size=”contain” custom_button_one=”on” button_one_text_size=”14px” button_one_bg_color=”#29cb8b” button_one_border_width=”12px” button_one_border_color=”#29cb8b” button_one_letter_spacing=”2px” button_one_font=”Poppins|600||on|||||” button_one_icon=”$||divi||400″ custom_button_two=”on” button_two_text_size=”14px” button_two_text_color=”#29cb8b” button_two_bg_color=”#ffffff” button_two_border_width=”12px” button_two_border_color=”#ffffff” button_two_letter_spacing=”2px” button_two_font=”Poppins|600||on|||||” button_two_icon=”$||divi||400″ min_height=”333.4px” custom_padding=”80px||2vw|||” subhead_font_size_tablet=”40px” subhead_font_size_phone=”30px” subhead_font_size_last_edited=”on|desktop” title_text_shadow_style=”preset3″ text_shadow_style=”preset3″ text_shadow_blur_strength=”0.65em” button_one_letter_spacing_hover=”2px” button_two_letter_spacing_hover=”2px” global_colors_info=”{}” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”on” button_one_letter_spacing__hover=”2px” button_two_letter_spacing__hover_enabled=”on” button_two_letter_spacing__hover=”2px” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”4.10.5″ _module_preset=”default” min_height=”860.7px” global_colors_info=”{}”][et_pb_column type=”1_2″ specialty_columns=”2″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_row_inner _builder_version=”4.10.5″ _module_preset=”default” width=”120%” max_width=”118%” module_alignment=”left” custom_margin=”37px|15px||15px|false|false” custom_padding=”|64px||0px|false|false” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”1_2″ _builder_version=”4.10.5″ _module_preset=”default” global_colors_info=”{}”][et_pb_text content_tablet=”” content_phone=”<\/p>\n

Fonction mitochondriale<\/h2>\n

” content_last_edited=”on|phone” _builder_version=”4.10.5″ text_font=”||||||||” header_font=”||||||||” header_2_font=”Raleway|700|||||||” header_2_font_size=”56px” header_2_line_height=”1.4em” custom_margin=”||20px|” header_2_font_size_tablet=”36px” header_2_font_size_phone=”” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

Fonction mitochondriale<\/h2>\n

[\/et_pb_text][et_pb_divider color=”#29cb8b” divider_weight=”3px” _builder_version=”4.10.5″ max_width=”90px” custom_margin=”||43px||false|false” animation_style=”slide” animation_direction=”left” animation_duration=”900ms” animation_intensity_slide=”46%” module_alignment_tablet=”” module_alignment_phone=”center” module_alignment_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.10.5″ text_font=”Amiko|300|||||||” text_font_size=”14px” link_font=”Poppins|600||on|on|||rgba(0,0,0,0.13)|” link_text_color=”#27cb8b” link_font_size=”13px” link_letter_spacing=”2px” header_font=”||||||||” header_3_font=”Raleway|700|||||||” header_3_line_height=”1.6em” custom_margin=”||||false|false” custom_padding=”|0px||||” hover_enabled=”0″ custom_css_main_element=”|| ” locked=”off” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

\u00a0The<\/span>\u00a0mitochondrion is an essential organelle involved in <\/span>ATP production<\/strong>, in <\/span>regulating cellular redox status<\/strong> et <\/span>cellular calcium homeostasis<\/strong> by interaction with endoplasmic reticulum.\u00a0 All these roles driving cellular function and create the optimal conditions for metabolic reactions. <\/span>Thus, this organelle constitutes a target of choice to develop innovative medicine therapeutics for a variety of diseases (cardiovacular, metabolic or anti-ageing for example).\u00a0<\/span><\/span><\/p>\n

\u00a0Mitochondrial dynamic network including mitochondrial biogenesis, fusion, fission and mitophagy contribute to eliminated damages mitochondrial. The mitochondrion contributes significantly to cellular oxidative stress <\/strong>by\u00a0the production of\u00a0reactive oxygen species<\/strong> that may lead to irreversible damage and mitochondrial dysfunction.\u00a0 Calcium cycle deregulation contribute to cell death signaling by openning mitochondrial <\/span>membrane channels can release pro-apoptotic factors on cytoplasm, leading to a cascade of dea<\/span>th cellular signals.\u00a0<\/span><\/p>\n

\u00a0In order to meet this need, Biophysium<\/em><\/strong> offers a wide range of experimental exploration and innovative methods, to assess different treatments and natural formulations on<\/span> mitochondrial structure and function <\/span>(toxicity and efficacy).<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/www.biophysium.com\/wp-content\/uploads\/2022\/04\/Capture-decran-2022-04-25-161255.png” alt=”nourriture” title_text=”Capture d\u2019\u00e9cran 2022-04-25 161255″ align=”center” disabled_on=”on|off|off” _builder_version=”4.10.5″ _module_preset=”default” width=”100%” width_tablet=”60%” width_phone=”” width_last_edited=”on|tablet” custom_margin=”22px||||false|false” custom_padding=”||||false|false” locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_slider _builder_version=”4.10.5″ _module_preset=”default” width=”97%” max_width=”100%” module_alignment=”left” min_height=”439px” height=”447px” custom_margin=”||-48px|||” global_colors_info=”{}”][et_pb_slide _builder_version=”4.10.5″ _module_preset=”default” background_image=”https:\/\/www.biophysium.com\/wp-content\/uploads\/2024\/04\/TMRM.jpg” background_enable_image=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][et_pb_slide _builder_version=”4.10.5″ _module_preset=”default” background_image=”https:\/\/www.biophysium.com\/wp-content\/uploads\/2024\/04\/Mitotracker.jpg” background_enable_image=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][et_pb_slide _builder_version=”4.10.5″ _module_preset=”default” background_image=”https:\/\/www.biophysium.com\/wp-content\/uploads\/2024\/04\/Merge.jpg” background_enable_image=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][et_pb_slide _builder_version=”4.10.5″ _module_preset=”default” background_image=”https:\/\/www.biophysium.com\/wp-content\/uploads\/2024\/04\/Rhod-2.jpg” background_enable_image=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][\/et_pb_slider][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|desktop” disabled_on=”on|on|on” admin_label=”information texte” _builder_version=”4.16″ module_alignment=”right” custom_margin=”140px||80px||false|false” custom_padding=”0px||0px||false|false” custom_padding_tablet=”||120px|” custom_padding_phone=”” disabled=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” width=”85%” max_width=”100%” custom_margin=”-1px|auto||auto||” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_font=”||||||||” header_font=”||||||||” header_2_font=”Raleway|700|||||||” header_2_font_size=”56px” header_2_line_height=”1.4em” custom_margin=”-115px||20px|||” header_2_font_size_tablet=”36px” header_2_font_size_phone=”” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Fonction mitochondriale<\/h2>\n

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\u00a0The<\/span>\u00a0mitochondrion is an essential organelle involved in <\/span>ATP production<\/strong>, in <\/span>regulating cellular redox status<\/strong> et <\/span>cellular calcium homeostasis<\/strong> by interaction with endoplasmic reticulum.\u00a0 All these roles driving cellular function and create the optimal conditions for metabolic reactions. <\/span>Thus, this organelle constitutes a target of choice to develop innovative medicine therapeutics for a variety of diseases (cardiovacular, metabolic or anti-ageing for example).\u00a0<\/span><\/span><\/p>\n

\u00a0 Mitochondrial dynamic network including mitochondrial biogenesis, fusion, fission and mitophagy contribute to eliminated damages mitochondrial. The mitochondrion contributes significantly to cellular oxidative stress <\/strong>by\u00a0the production of<\/span>\u00a0<\/span>reactive oxygen species<\/strong> that may lead to irreversible damage and mitochondrial dysfunction.\u00a0 Calcium cycle deregulation contribute to cell death signaling by openning mitochondrial membrane channels can release pro-apoptotic factors on cytoplasm, leading to a cascade of death cellular signals.\u00a0<\/span><\/p>\n

\u00a0 In order to meet this need, Biophysium<\/em><\/strong> offers a wide range of experimental exploration and innovative methods, to assess different treatments and natural formulations on mitochondrial structure and function <\/span>(toxicity and efficacy).<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.10.5″ _module_preset=”default” max_width=”100%” custom_margin=”|auto||151px||” custom_padding=”|||31px||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.biophysium.com\/wp-content\/uploads\/2022\/04\/Capture-decran-2022-04-25-161255.png” alt=”nourriture” title_text=”Capture d\u2019\u00e9cran 2022-04-25 161255″ align=”center” _builder_version=”4.10.5″ _module_preset=”default” width=”53%” width_tablet=”60%” width_phone=”” width_last_edited=”on|tablet” custom_padding=”||||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”off|desktop” admin_label=”in vitro ” module_id=”invitro-nutraceutique” _builder_version=”4.10.5″ background_color=”#edf1f4″ max_width=”100%” module_alignment=”center” min_height=”514.4px” custom_margin=”-18px||-18px||true|false” custom_padding=”15px||15px||true|false” custom_padding_tablet=”||120px|” global_colors_info=”{}”][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.10.5″ custom_margin=”55px|auto||auto||” custom_padding=”|||” locked=”off” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text content_tablet=”” content_phone=”<\/p>\n

Dynamique mitochondriale<\/h2>\n

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Dynamique mitochondriale<\/h2>\n

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Fission\u2013fusion balance\u00a0<\/strong><\/h4>\n

<\/h4>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” border_color_right=”#25468F” global_colors_info=”{}”][et_pb_text _builder_version=”4.10.5″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Mitochondrial architecture<\/strong><\/h4>\n

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Size ans shape<\/strong><\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.16″ _module_preset=”default” border_width_top=”2px” border_color_top=”#e0e0e0″ global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” border_color_right=”#1E3865″ global_colors_info=”{}”][et_pb_text _builder_version=”4.10.5″ _module_preset=”default” custom_padding=”||0px|||” global_colors_info=”{}”]<\/p>\n

Swelling mitochondrial<\/strong><\/h4>\n

<\/h4>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” border_color_right=”#25468F” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”exploration” module_id=”exploration-neutraceutique” _builder_version=”4.16″ min_height=”673.1px” custom_margin=”8px||8px||true|false” custom_padding=”0||||false|false” global_colors_info=”{}”][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.16″ custom_padding=”|||” locked=”off” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text content_tablet=”” content_phone=”<\/p>\n

Fonction mitochondriale<\/h5>\n

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Fonction mitochondriale<\/h5>\n

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Membrane permeability<\/h4>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” border_color_right=”#25468F” global_colors_info=”{}”][et_pb_text _builder_version=”4.10.5″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Membrane potential<\/h4>\n

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Oxygen consumption<\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.16″ _module_preset=”default” border_width_top=”2px” border_color_top=”#e0e0e0″ global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” border_color_right=”#1E3865″ global_colors_info=”{}”][et_pb_text _builder_version=”4.10.5″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Interaction Mitochondrial \/ Endoplasmic reticulum<\/h4>\n

MAM<\/p>\n

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Membrane channels<\/h4>\n

MCU, mPTP, etc…<\/p>\n

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\u00a0 \u00a0Calcium homeostasis and\u00a0 \u00a0 calcium retention capacity<\/h4>\n

CRC<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.16″ _module_preset=”default” border_width_top=”2px” border_color_top=”#e0e0e0″ global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” border_color_right=”#1E3865″ global_colors_info=”{}”][et_pb_text _builder_version=”4.10.5″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

ROS production and oxidative stress<\/h4>\n

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Biochemical analysis<\/h4>\n

Proteomic, metabolomic<\/p>\n

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ATP production<\/h4>\n

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Pro-apoptotic factors and cell death<\/h4>\n

Apoptosis, necrosis, autophagy<\/p>\n

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Dynamique mitochondriale<\/strong><\/p>\n

[\/et_pb_text][et_pb_image src=”https:\/\/www.biophysium.com\/wp-content\/uploads\/2021\/05\/explorer.png” alt=”rongeur” title_text=”explorer” url=”#exploration-neutraceutique” align=”center” _builder_version=”4.10.5″ _module_preset=”default” width=”50px” width_last_edited=”off|desktop” custom_margin=”||||false|false” custom_padding=”||5px||false|false” global_colors_info=”{}” width__hover_enabled=”on|hover” width__hover=”70px”][\/et_pb_image][et_pb_text _builder_version=”4.10.5″ _module_preset=”default” link_option_url=”#exploration-neutraceutique” global_colors_info=”{}”]<\/p>\n

Fonction mitochondriale<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|on” admin_label=”top” module_class=”soum” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” positioning=”fixed” position_origin_f=”bottom_right” horizontal_offset=”0px” z_index=”9999″ width=”55px” global_colors_info=”{}”][et_pb_row disabled_on=”off|off|on” _builder_version=”4.16″ _module_preset=”default” width=”100%” module_alignment=”center” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.biophysium.com\/wp-content\/uploads\/2021\/06\/top.png” alt=”top” title_text=”top” url=”#nutrition” align=”center” _builder_version=”4.16″ _module_preset=”default” width=”50px” width_tablet=”” width_phone=”” width_last_edited=”on|desktop” custom_margin=”||||false|false” custom_padding=”||||false|false” global_colors_info=”{}” width__hover_enabled=”off|desktop” width__hover=”70px”][\/et_pb_image][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_margin=”-35px||||false|false” link_option_url=”#nutrition” global_colors_info=”{}”]<\/p>\n

Haut<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

Mitochondrial function\u00a0The\u00a0mitochondrion is an essential organelle involved in ATP production, in regulating cellular redox status and cellular calcium homeostasis by interaction with endoplasmic reticulum.\u00a0 All these roles driving cellular function and create the optimal conditions for metabolic reactions. Thus, this organelle constitutes a target of choice to develop innovative medicine therapeutics for a variety of […]<\/p>","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\n

Mitochondrial function<\/p>\n","_et_gb_content_width":"","footnotes":""},"class_list":["post-2038","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.biophysium.com\/fr\/wp-json\/wp\/v2\/pages\/2038","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biophysium.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.biophysium.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.biophysium.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biophysium.com\/fr\/wp-json\/wp\/v2\/comments?post=2038"}],"version-history":[{"count":47,"href":"https:\/\/www.biophysium.com\/fr\/wp-json\/wp\/v2\/pages\/2038\/revisions"}],"predecessor-version":[{"id":3448,"href":"https:\/\/www.biophysium.com\/fr\/wp-json\/wp\/v2\/pages\/2038\/revisions\/3448"}],"wp:attachment":[{"href":"https:\/\/www.biophysium.com\/fr\/wp-json\/wp\/v2\/media?parent=2038"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}