The mitochondrion is an essential organelle involved in ATP production, in regulating cellular redox status and cellular calcium homeostasis by interaction with endoplasmic reticulum. All these roles driving cellular function and create the optimal conditions for metabolic reactions. Thus, this organelle constitutes a target of choice to develop innovative medicine therapeutics for a variety of diseases (cardiovacular, metabolic or anti-ageing for example).
Mitochondrial dynamic network including mitochondrial biogenesis, fusion, fission and mitophagy contribute to eliminated damages mitochondrial. The mitochondrion contributes significantly to cellular oxidative stress by the production of reactive oxygen species that may lead to irreversible damage and mitochondrial dysfunction. Calcium cycle deregulation contribute to cell death signaling by openning mitochondrial membrane channels can released pro-apoptotic factors on cytoplasm leading to a cascade of death cellular signals.
In order to meet this need, Biophysium offers a wide range of experimental exploration and innovative methods, to assess different treatments and natural formulations on mitochondrial structure and function (toxicity and efficacy).
Size ans shape
Interaction Mitochondrial / Endoplasmic reticulum
MCU, mPTP, etc…
Calcium homeostasis and calcium retention capacity
ROS production and oxidative stress
Pro-apoptotic factors and cell death
Apoptosis, necrosis, autophagy