The future of innovation
Biophysium is not just a CRO, it’s a leading R&D company. Our researchers and experts are developing tomorrow’s health products.
Our pipeline and technologies
Mitophysium Project
This project is part of the development of innovative natural non-medicinal treatments that have an impact on mitochondrial function. The fields of application could cut across a wide range of pathologies characterised by mitochondrial dysfunction, such as metabolic and cardiac diseases, ageing and certain cancers involving oxidative stress and alteration of the calcium cycle.
The aim is to prevent the development of pathological phenotypes (hypertension, heart failure, diabetes, obesity, cancer).
Although this project is part of a health theme, it should enable us to highlight the benefits of nutritional strategies and the health effects of products rich in compounds of interest, opening up new innovative research to improve the management of patients with mitochondrial dysfunction.
In this way, we are developing formulations intended to be marketed. We are currently in the pre-clinical testing phase.
Echophysium Project
For a long time, the study of myocardial function was limited to analyses based on 2-dimensional (2D) cardiac slices. However, 2D analyses have a number of limitations, as they do not allow us to study the heart chambers in their entirety. This is certainly the case for the left ventricle and atrium, but also and above all for the right ventricle, which has a very complex geometry, wrapping around the left ventricle. In this context, the aim of the project presented here is to develop new tools for analysing myocardial function based on 3D echocardiographic recordings. The 3D analyses enable deformations to be assessed as a whole. After calculation, it is possible to access the orientation of myocardial fibres, which may be modified after physiological or pathological remodelling. Another area of innovation at the heart of this project will be to assess the interaction between myocardial function and intra-ventricular flow. While one might think that blood flows in and out of the left ventricle in a linear fashion, previous MRI studies have shown that the blood follows a specific trajectory in order to improve energy output and reduce cardiac work per beat.
The aim of this project will be to develop new echocardiographic tools based on 3D assessments. These new tools will include an assessment of the global deformations (principal deformations) applied to the different cardiac cavities, as well as an assessment of intraventricular flows and their interaction with left ventricular mechanics.
They will enable clinicians to make better diagnoses and improve patient care.
We are in the clinical trial phase.
