Biophysium is an innovative bio-health company specialized in the conception and realization of pre-clinical (in and ex–vivo) and clinical research services for cardiovascular health, metabolic diseases prevention and nutraceutical. We support and guide you in your research for innovation in bio-health in order to increase visibility and scientific credibility of your unique project by providing a high level of evidence.

 Biophysium has been able to develop numerous skills to investigate the effects of different protective strategies (nutraceutical, physical exercise, medication, etc.) on cardiovascular health and metabolic diseases, starting from evaluations at the cellular level up to clinical effects, through pre-clinical models. Thus, we offer you our skills in order to 1 / optimize processes or formulations, in particular based on natural substances, 2 / generate proofs of concept and finally 3 / test, develop and identify the mechanisms of action of molecules / micronutrients / formulations which impact the development of cardiovascular, metabolic and inflammatory diseases.

 Biophysium wish to offer its clients, whether they are health, plant or biochemistry professionals, a full range of tailor-made experimental solutions adapted to your unique project. Flexibility, extremely reactivity and human-sized organization of our company allows us to design and implement specific protocols by combining our expertise, our innovative technicals and regulatory aspects.

All this allows us to provide you with the most appropriate and least costly answers for your project, in order to assess the potential of your drug candidate by effective studies.

 Biophysium is particularly involved in the implementation, optimization and validation of new innovative models and technicals recognized by the scientific community to induce better predictability of results in order to anticipate clinical trials and improve their the success rate.

 In addition to our research services, we can propose you consulting services, bibliographic monitoring, assistance in drafting of referrals for ethics committees, assistance in publication of scientific articles and specific adapted training to your needs.

 Biophysium pays particular attention to sustainable development, health protection and the training of its employees, as well as to ethics and animal welfare.
Regular training of all our employees in our environmental management system enables us to minimise the impact of our activities by adopting the most energy-efficient and ecological options (water consumption, sorting and recycling of waste in particular). Hazardous waste such as solvents, chemical and biological waste is disposed of using specific procedures that comply with the latest European Union regulations.
All experimental procedures are carried out in strict compliance with the « Guide for the Care and Use of Laboratory Animals » described by the US National Institutes of Health (NIH, National Academies Press US, 8th edition, 2011) and in accordance with Directive 2010/63 EU of the European Parliament on the use of animals in laboratories, as well as the regulations of the French Ministry of Agriculture and Food.

 The animal facility in which pre-clinical studies are conducted has been approved and authorised by the veterinary authorities and is regularly inspected.
All pre-clinical and clinical studies begin only after receiving the approval and validation of the ethics committee or the personal protection committee issued by the Ministry of Higher Education, Research and Innovation.
Compulsory qualifications and ongoing staff training ensure that we are up to date with the latest BEA recommendations on rearing conditions, environmental enrichment, physical activity and animal care to reduce stress. All experiments are carried out in dedicated rooms that comply with the latest standards.
 Biophysium actively supports the three Rs principle (Refine, Reduce, Replace) in pre-clinical research to minimise the use of laboratory animals and potentially painful or invasive procedures by favouring alternative methods.